2024

Swamynathan MM, Kuang S, Watrud KE, Doherty MR, Gineste C, Mathew G, Gong GQ, Cox H, Cheng E, Reiss D, Kendall J, Ghosh D, Reczek CR, Zhao X, Herzka T, Špokaitė S, Dessus AN, Kim ST, Klingbeil O, Liu J, Nowak DG, Alsudani H, Wee TL, Park Y, Minicozzi F, Rivera K, Almeida AS, Chang K, Chakrabarty RP, Wilkinson JE, Gimotty PA, Diermeier SD, Egeblad M, Vakoc CR, Locasale JW, Chandel NS, Janowitz T, Hicks JB, Wigler M, Pappin DJ, Williams RL, Cifani P, Tuveson DA, Laporte J, Trotman LC, Dietary pro-oxidant therapy by a vitamin K precursor targets PI 3-Kinase VPS34 function. Science. 2024, Oct 25;386(6720) PubMed

Serio RS, Armin Scheben A, Lu B, Gargiulo DV,  Patruno L,  Buckholtz CL,  Chaffee RJ,  Jibilian MC, Persaud SG,  Staklinski SJ,  Hassett R,  Brault LM, Ramazzotti D,  Barbieri CE,  Siepel AC, Nowak DG, Clonal lineage tracing with somatic delivery of recordable barcodes reveals migration histories of metastatic prostate cancer. Cancer Discov. 2024, Oct 4;14(10):1990-2009. PubMed

2023

van er Mijn JC, Laursen KB, Fu L, Khani F, Dow LE, Nowak DG, Chen Q, Gross S, Nanus DM, Gudas LJ, Novel genetically engineered mouse models for clear cell renal carcinoma. Sci Rep. 2023, May 22;13(1):8246 PubMed

2022

Taranda J, Mathew G, Watrud K, El-Amine N, Lee MF, Elowsky C, Bludova A, Escobar Avelar S, Nowak DG, Wee TL, Wilkinson JE, Trotman LC, Osten P. Combined whole-organ imaging at single-cell resolution and immunohistochemical analysis of prostate cancer and its liver and brain metastases. Cell Rep 2021, Nov 16;37(7):110027 PubMed

2019

Nowak DG, Katsenelson K, Watrud K, Chen M, Mathew G, D’Andrea V, Lee MF, Swamynathan M, Casanova-Salas I, Jibilian M, Buckholtz C, Ambrico A, Chun-Hao Pan, Wilkinson JE, Newton A, Trotman LC. The PHLPP2 phosphatase is a druggable driver of prostate cancer progression. J Cell Biol. 2019, Jun 03;(218)(6) PubMed

2017

Alexander J, Jude Kendall J, McIndoo J, Rodgers L, Aboukhalil R, Stepansky A, Sun G, Riggs M, Cox H, Hakker I, Nowak DG, Laze J, Llukani E, Srivastava A, Gruschow S, Singh S, Robinson B, Tewari A, Atwal G, Trotman LC, Lepor H, Hicks J, Wigler M, Krasnitz A.  Utility of Single-Cell Genomics in Diagnostic Evaluation of Prostate Cancer. Cancer Res. 2017, 78(2):348-358. PubMed

Chen M & Nowak DG, Navneet N, Robinson B, Watrud K, Ambrico A, Herzka TM, Zeeman ME, Minderer M, Zheng W, Ebbesen SH, Plafker KS, Stahlhud C, Wang VMY, Wills L, Nasar A, Castillo-Martin M, Cordon-Cardo C, Wilkinson JE, Powers S, Sordella R, Altorki NK, Mittal V, Stiles BM, Plafker SM, Trotman LC.The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein. J Cell Biol. 2017, 216(3):641-656. PubMed

Senturk S, Shirole NH, Nowak DG, Corbo V, Pal D, Vaughan A, Tuveson DA, Trotman LC, Kinney JB, Sordella R.  Rapid and tunable method to temporally control gene editing based on conditional Cas9 stabilization. Nat Commun. 2017, 8:14370.PubMed

2015

Nowak DG, Cho H, Herzka T, Watrud K, DeMarco DV, M Y Wang V, Senturk S, Fellmann C, Ding D, Beinortas T et al..  2015.  MYC Drives Pten/Trp53-Deficient Proliferation and Metastasis due to IL6 Secretion and AKT Suppression via PHLPP2. Cancer Discov. 2015, 5(6):636-51. PubMed